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KMID : 0379520040200030187
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한국독성학회지
2004 Volume.20 No. 3 p.187 ~ p.193
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Myeloperoxidase Polymorphism and Vitamin C Levels during Pregnancy Affect Maternal Oxidative Stress and Their Neonatal Birth Weights
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Park Bo-Hyun
Kim Young-Ju
Park Eun-Ae
Lee Hwa-Young
Ha Eun-Hee
Park Jong-Soon
Kim Jung-Yeon
Hong Yong-Tae
Park Hye-Sook
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Abstract
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This study aimed to determine the association of maternal oxidative stress and adverse pregnancy outcome with serum vitamin C concentration and a myeloperoxidase (MPO) genetic polymorphism during pregnancy. We investigated 450 pregnant women who visited Ewha Womans University Hospital for prenatal care during gestational weeks 24～28. During the second trimester, we measured serum vitamin C levels and urinary 8-hydroxyde-2’’’’-deoxyguanosine (8-OHdG) and malondialdehyde (MDA) as an oxidative stress biomarker. We determined the presence of a maternal MPO polymorphism (G-to-A substitution at nucleotide 463) using a PCR-RFLP assay. We compared the level of oxidative stress and birth weight with the vitamin C concentration and the presence of the MPO polymorphism. The mean level of maternal oxidative stress tended to be higher and the birth weight lower for MPO type A/A than for types A/G and G/G. Vitamin C levels above the 75 percentiles were associated with reduced concentrations of urinary MDA and 8-OHdG but increased birth weight. Our data demonstrate that oxidative stress and neonatal birth weight are associated with the MPO genetic polymorphism, with the association modified by the maternal vita-min C levels.
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KEYWORD
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Myeloperoxidase, Polymorphism, Vitamin C, Oxidative Stress, Birth Weight, Pregnancy
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